a variation in circumstances or fortune at different times in your life or in the development of something
<noun.event> the project was subject to the usual vicissitudes of exploratory research
mutability in life or nature (especially successive alternation from one condition to another)
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Vicissitude \Vi*cis"si*tude\, n. [L. vicissitudo, fr. vicis change, turn: cf. F. vicissitude. See {Vicarious}.] 1. Regular change or succession from one thing to another; alternation; mutual succession; interchange.
God made two great lights . . . To illuminate the earth and rule the day In their vicissitude, and rule the night. --Milton.
2. Irregular change; revolution; mutation.
This man had, after many vicissitudes of fortune, sunk at last into abject and hopeless poverty. --Macaulay.