寡聚脱氧核苷酸 [
guǎ jù tuō yǎng hè gān suān]
[生化] oligodeoxynucleotide
- 目的:观察端粒酶反义寡聚脱氧核苷酸对人胃癌细胞株的作用。
Objective To observe the effect of telomerase antisense oligodexynucleotides on human gastric cancerous cell line. - 结果:端粒酶反义寡聚脱氧核苷酸能诱导人胃癌细胞凋亡,抑制端粒酶活性。
Telomerase activity were detected by TRAPELISA. Results: Telomerase antisense oligodeoxynucleotides acted as a specific growth inhibitor to gastric cancer cell line. - 合成的富含嘌呤或嘧啶的脱氧寡核苷酸可与双链DNA内特定的同聚嘌呤、同聚嘧啶序列结合形成稳定的三螺旋结构(三链DNA)。
Synthetic purine rich or pyridine rich oligonucleotides have been shown to form stable triplex by binding to specific homopurine homopyridine sequences in double stranded DNA.